文章成果

Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency

Biological Cryo-EM
  • Journal of Structural Biology 177: 589-601 (2012)

Bammes BE, Rochat RH, Jakana J, Chen DH, Chiu W

Abstract:The first published cryo-EM reconstructions far beyond 2/3 Nyquist. DDD performance is comprehensively evaluated compared to CCD.



Movies of Ice-Embedded Particles Enhance Resolution in Electron Cryo-Microscopy

Biological Cryo-EM
  • Structure 20: 1823-1828 (2012)

Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N

Abstract:The first high-resolution cryo-EM reconstruction from a DDD, demonstrating the improvement in data quality from motion correction.



Initial evaluation of a direct detection device detector for single particle cryo-electron microscop

  • Journal of Structural Biology 176: 404-408 (2011)

Milazzo AC, Cheng A, Moeller A, Lyumkis D, Jacovetty E, Polukas J, Ellisman MH, Xuong NH, Carragher B, Potter CS

Abstract:The first cryo-EM single particle reconstruction with a direct detection camera, and a comparison of GroEL on a DDD and CCD.



Characterization of a direct detection device imaging camera for transmission electron microscopy

  • Ultramicroscopy 110: 744-747 (2010)

Milazzo AC, Moldovan G, Lanman J, Jin L, Bouwer JC, Klienfelder S, Peltier ST, Ellisman MH, Kirkland AI, Xuong NH

Abstract:A complete characterization of a novel direct detection device (DDD) camera for transmission electron microscopy.



Applications of direct detection device in transmission electron microscopy

  • Journal of Structural Biology 161: 352-358 (2008)

Jin L, Milazzo AC, Kleinfelder S, Li S, Leblanc P, Duttweiler F, Bouwer JC, Peltier ST, Ellisman MH, Xuong NH

Abstract:The first tomography dataset from a DDD camera, along with the first demonstration of drift correction using a DDD.



Active pixel sensor array as a detector for electron microscopy

  • Ultramicroscopy 104: 152-159 (2005)

Milazzo AC, Leblanc P, Duttweiler F, Jin L, Bouwer JC, Peltier S, Ellisman M, Bieser F, Matis HS, Wieman H, Denes P, Kleinfelder S, Xuong NH

Abstract:Initial tests of an active pixel sensor (APS) array with an area of 64 x 64 pixels and 20 micron pixels.